Services that turn cryo-EM data into decisions
Optimised gene therapy vectors via structural analysis and engineering
Harnessing the power of cryogenic electron microscopy (cryo-EM), we provide three-dimensional structural analysis essential for the advancement of gene therapy vectors. A significant challenge in the deployment of vectors like the adeno-associated virus (AAV) is circumventing the humoral immune response, which targets these vectors often restricting their use. Our services are pivotal in identifying the atomic detail of antibody epitopes, enabling the design of vectors with reduced visibility to the immune system. This targeted approach minimizes the immune response, paving the way for more effective gene therapies.
Innovative drug design through molecular visualisation
At the core of pioneering drug design is the ability to visualize and understand the intricate interactions between small molecules and their target proteins. Utilizing state-of-the-art cryogenic electron microscopy (cryo-EM), we bring unparalleled clarity to the binding processes of potential therapeutics to a wide array of drug targets, including kinases and critical membrane proteins such as G-protein-coupled receptors (GPCRs). This visualization capability allows us to capture the dynamic engagement between small molecules and their binding sites, facilitating the precise design of drugs that are both highly specific and efficacious.
Three-dimensional nanoparticle quantification
Our specialized service focuses on the three-dimensional quantification of a diverse spectrum of nanoparticles, ranging from bio-inspired materials to other soft matter constructs like liposomes, extracellular vesicles (EVs) and DNA origamis. Through our advanced analysis techniques, we can accurately characterize particles within the size range of 10-500 nanometers in their native state. This detailed quantification is essential for a variety of applications, including drug delivery systems, diagnostics, and nanotechnology applications. We provide precise measurements of particle size, distribution, and 3D structure, empowering you to leverage the full potential of your nanoscale materials.
Advanced vaccine development through structural insight
In the realm of vaccine development, understanding the structural intricacies of vaccine candidates is crucial. At Nanometria, we employ cryogenic electron microscopy (cryo-EM) coupled with single-particle analysis to reveal the detailed architectures of inactivated viruses and virus-like particles (VLPs) and their interactions with antibodies. This structural elucidation is fundamental in assessing the immunogenic potential of vaccine candidates. By visualizing these complexes at the nanoscale, we provide our clients with critical insights that guide the refinement of vaccine design, ensuring that they elicit the desired immune response effectively.
How we work
Step 1 — Scoping and plan
You share the question and data status. We return a short plan with options, check points and timelines.
Step 2 — Analysis
We run state-of-the-art cryo-EM data processing pipelines on a secure HPC environment. We can tailor methods to your data or advise you on data analysis approaches.
Step 3 — Results and decisions
You receive models, figures, and a concise report. We can present to your team on request.
Nanometria 