Services that turn cryo-EM data into decisions
AAV capsid analysis
Epitope mapping and capsid engineering support for gene therapy
High-resolution structures of AAV capsids and AAV–Fab complexes, using localized reconstruction to resolve bound antibodies, epitopes, and engineered surface features. For pre-clinical immunogenicity assessment, rational capsid redesign, and IP-defensible structural evidence. Typically 3 weeks for 3–6 complexes.
Our approach uses Oxford-developed localized reconstruction methods to overcome the symmetry mismatch between icosahedral capsids and bound antibodies. This enables atomic-level mapping of epitopes that would be invisible to conventional single-particle pipelines.
Viral antigens & VLPs
Structural characterization for vaccine development
Single-particle analysis of icosahedral antigens and VLPs, plus cryo-ET and subtomogram averaging of enveloped viruses and their glycoprotein spikes. For immunogen design, antibody epitope mapping on pleiomorphic particles, and batch comparability, where symmetry-breaking or flexibility rules out conventional pipelines.
We specialize in structural characterization of vaccine particles that exhibit conformational flexibility or other features that make them challenging for standard cryo-EM approaches. Our cryo-electron tomography expertise enables the analysis of enveloped viruses and the organization of glycoprotein surfaces at native conditions.
Nanoparticle characterisation
LNPs, extracellular vesicles, liposomes, and engineered soft matter
Three-dimensional quantification of pleiomorphic nanoparticles in their native hydrated state using cryo-ET and subtomogram averaging. For mRNA and siRNA delivery programs, EV therapeutics, and engineered particles, where DLS and negative-stain EM don’t answer the question, including size distribution, payload localization, and structural heterogeneity across batches.
Lipid nanoparticles (LNPs) for RNA delivery, extracellular vesicles, and other membrane-based therapeutic carriers require structural analysis that preserves their native hydrated state. Our cryo-electron tomography approach captures the three-dimensional organization of these systems without the artifacts introduced by drying or staining.
How we work
Step 1 — Scoping and plan
You share the question and data status. We return a short plan with options, checkpoints and timelines.
Step 2 — Analysis
We run state-of-the-art cryo-EM data-processing pipelines in a secure HPC environment. We can tailor methods to your data or advise you on data analysis approaches.
Step 3 — Results and decisions
You receive models, figures, and a concise report. We can present to your team on request.
